| Disadvantage | Cost |
| Absent-Mindedness | -3D |
| Acceleration Weakness? | -1D |
| ACCRS | -2D |
| Addiction | Variable |
| Albinism | -2D |
| Alcoholism? | -3D/-4D |
| Amnesia? | -2D/-5D |
| Bad Back? | -3D/-5D |
| Bad Sight | -2D |
| Bad Smell? | -2D |
| Bad Temper | -2D |
| Berserk | -3D |
| Blindness | -10D |
| Bloodlust | -2D |
| Bully? | -2D |
| Callous? | -1D |
| Code of Honor? | -1D to -3D |
| Color Blindness | -2D |
| Combat Paralysis? | -3D |
| Compulsive Behavior? | -1D to -3D |
| Compulsive Lying? | -3D |
| Cowardice? | -2D |
| Cyber Rejection | -2D |
| Deafness | -4D |
| Delicate Metabolism? | -4D/-8D |
| Delusions? | -1, -1D, -2D, or -3D |
| Dependency? | Variable |
| Disembodied Brain? | -20D |
| Disowned? | -1D/-3D |
| Disturbing Voice | -2D |
| Duty ? | extra -1D |
| Dwarfism | -3D |
| Dyslexia? | -1D or -3D |
| Easy to Read | -2D |
| Epilepsy? | -6D |
| Eunuch? | -1D |
| Extra Sleep | -2/level, max 4 levels |
| Fanaticism? | -3D |
| Fat? | -2D/4D |
| G-Intolerance? | -2D/-4D |
| Gigantism? | -2D |
| Gluttony | -1D |
| Greed? | -3D |
| Gullibility? | -2D |
| Hard of Hearing? | -2D |
| Hemophilia? | -6D |
| Honesty? | -2D |
| Hunchback? | -2D |
| Illiteracy? | -2D |
| Impulsiveness? | -2D |
| Indecisive | -2D |
| Insomniac? | -2D or -3D |
| Intolerance? | -1D/-2D |
| Jealousy? | -2D |
| Kleptomania? | -3D |
| Lame? | -3D, -5D, or -7D |
| Laziness? | -2D |
| Lecherousness? | -3D |
| Light Sleeper? | -1D |
| Low Pain Threshold? | -2D |
| Megalomaia? | -2D |
| Migrane? | -1D to -4D |
| Miserliness? | -2D |
| Missing Digit? | -1 to -1D |
| Mistaken Identity? | -1D |
| Mute? | -5D |
| Night Blindness? | -2D |
| Nightmares | -1D |
| No Sense of Smell or Taste ? | -1D |
| Oblivious | -2 |
| Odious Personal Habits | -1D, -2D, or -3D |
| One Arm? | -4D |
| One Eye? | -3D |
| One Hand? | -3D |
| Overconfidence? | -2D |
| Overweight | -1D |
| Pacifism | -3D or -6D |
| Paranoia? | -2D |
| Phobais? | Variable |
| Poverty | Variable |
| Primitive | -1D/tech level |
| Pyromania? | -1D |
| Quadriplegic | -10D |
| Sadism? | -3D |
| Secret? | Variable |
| Secret Identity? | Variable |
| Sense of Duty? | -1D to -4D |
| The Shakes | -2D |
| Shyness? | -1D, -2D or -3D |
| Skinny? | -1D |
| Social Stigma | -1D, -2D, -3D, -4D |
| Solipist | -2D |
| Split Personality? | -2D or -3D |
| Sterile | -2 |
| Stubbornness? | -1D |
| Stuttering? | -2D |
| Susceptibility to Poison | -1D |
| Terminally Ill | -10D/15D/20D |
| Tourette's Syndrome? | Variable |
| Truthfulness? | -1D |
| Unfit | -1D |
| Unluckiness | -2D |
| Unnatural Feature | -1D/feature |
| Very Unfit | -3D |
| Vow? | -1 to -3D |
| Weak Immune System | -6D |
| Xenophilia | -1D/-3D |